For the first time since 2017, the National Geographic Orion is sailing the Mediterranean, offering voyages that marry active exploration with cultural discovery. For the return to this storied region, the itineraries are infused with an in-depth discovery of regional wines selected by Food & Wine’s Executive Wine Editor, Ray Isle—but beyond the culinary delights, there is more to explore. Here are some highlights from each voyage to help you decide which of these new Mediterranean expeditions is the best fit for your interests.